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Corona-virus: what do scientists know about Covid-19 so far?

Corona-virus: what do scientists know about Covid-19 so far?

Medical researchers have been studying everything we know about Covid-19. What have they learned – and is it enough to halt the pandemic?

Corona-viruses have been causing problems for humanity for a long time. Several versions are known to trigger common colds and more recently two types have set off outbreaks of deadly illnesses: severe acute respiratory syndrome (Sars) and Middle East respiratory syndrome (Mers).

A model of a betacoronavirus, the virus linked to Covid-19
But their impact has been mild compared with the global havoc unleashed by the corona-virus that is causing the Covid-19 pandemic. In only a few months it has triggered lock-downs in dozens of nations and claimed more than 100,000 lives. And the disease continues to spread.
That is an extraordinary achievement for a spiky ball of genetic material coated in fatty chemicals called lipids, and which measures 80 billionths of a meter in diameter. Humanity has been brought low by a very humble assailant.

On the other hand, our knowledge about the Sars-CoV-2, the virus that causes Covid-19, is also remarkable. This was an organism unknown to science five months ago. Today it is the subject of study on an unprecedented scale. Vaccines projects proliferate, antiviral drug trials have been launched and new diagnostic tests are appearing.
The questions are therefore straightforward: what have we learned over the past five months and how might that knowledge put an end to this pandemic?

Where did it come from and how did it first infect humans?

The Sars-CoV-2 virus almost certainly originated in bats, which have evolved fierce immune responses to viruses, researchers have discovered. These defenses drive viruses to replicate faster so that they can get past bats’ immune defenses. In turn, that transforms the bat into a reservoir of rapidly reproducing and highly transmissible viruses. Then when these bat viruses move into other mammals, creatures that lack a fast-response immune system, the viruses quickly spread into their new hosts. Most evidence suggests that Sars-CoV-2 started infecting humans via an intermediary species, such as pangolins.

Source: https://www.theguardian.com/world/2020/apr/30/coronavirus-what-do-scientists-know-about-covid-19-so-far

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